AKT3 blocking peptide product blog
Tags: Blocking Peptide; AKT3; AKT3 blocking peptide; AKT3 (S472);
The AKT3 akt3 (Catalog #MBS9225148) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The AKT3 akt3 product has the following accession number(s) (GI #12643943) (NCBI Accession #Q9Y243.1) (Uniprot Accession #Q9Y243). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
Cellular Location: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note: Membrane-associated after cell stimulation leading to its translocation. Tissue Location: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. Brain Diseases, Congenital Abnormalities, Liver Diseases, Lung Neoplasms, Malformations of Cortical Development, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Experimental, Ovarian Neoplasms, Skin Neoplasms are some of the diseases may be linked to Phospho-AKT3(S472) Antibody Blocking peptide. AKT3 also interacts with the following gene(s): FOXO1, FOXO3, MTOR, PDPK1, PHLPP1, PHLPP2, PIK3CA, PTEN, TSC1, TSC2.