AIFM1 blocking peptide product blog
Tags: Blocking Peptide; AIFM1; AIFM1 blocking peptide;
The AIFM1 aifm1 (Catalog #MBS9227920) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The AIFM1 aifm1 product has the following accession number(s) (GI #13431764) (NCBI Accession #O95831.1) (Uniprot Accession #O95831). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces \'parthanatos\' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Cellular Location: Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note: Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region Isoform 5: Cytoplasm. Tissue Location: Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers. The following patways have been known to be associated with this gene. Brain Diseases, Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Liver Diseases, Liver Neoplasms, Movement Disorders, Necrosis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to AIFM1 Antibody (N-term) Blocking Peptide. AIFM1 also interacts with the following gene(s): BAD, BAX, BCL2, BCL2L1, CASP3, ENDOG, PARP1, XIAP. Blood, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein.