ADORA2A assay system product blog
Tags: ADORA2A; Assay System; Adenosine A2A; ADORA2A assay system;
The ADORA2A n/a (Catalog #MBS433610) is an Assay System and is intended for research purposes only. The product is available for immediate purchase.cAMP dependent human ADORA2A cell-based assay; cell-based high-throughput screening of human ADORA2A inhibitors. Researchers should empirically determine the suitability of the ADORA2A n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Background/Introduction: ADORA2A is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders.