|The ACVR1B acvr1b (Catalog #MBS9227268) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ACVR1B acvr1b product has the following accession number(s) (GI #547775) (NCBI Accession #P36896.1) (Uniprot Accession #P36896). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. Blood, Bone, Brain, Embryonic Tissue, Heart, Lung, Muscle, Ovary, Placenta, Prostate tissues are correlated with this protein. The following patways have been known to be associated with this gene. Brain Diseases, Cardiovascular Diseases, Congenital Abnormalities, Fibrosis, Hypertension, Inflammation, Kidney Diseases, Lung Diseases, Nervous System Diseases, Vascular Diseases are some of the diseases may be linked to Activin A Receptor Type IB (ACVR1B) Antibody (Center) Blocking peptide.