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AC220 kinase inhibitor product blog

Tags: Kinase Inhibitor; AC220; AC220 kinase inhibitor;

     The AC220 n/a (Catalog #MBS8506513) is a Kinase Inhibitor and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given kinase inhibitor. We\'ve tested the AC220 with the following immunoassay(s):
Testing Data
Testing Data AC220.

AC220 (Quizartinib) is an uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 +/-0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor. [1][2].

Solubility: DMSO >=112mg/mL - Water <1mg/mL - Ethanol >=4mg/mL. Formula: C29H32N6O4S
CAS Number: 950769-58-1.
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