Abl2 blocking peptide product blog
Tags: Blocking Peptide; ABL2; ABL2 blocking peptide;
The Abl2 abl2 (Catalog #MBS9230131) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Abl2 abl2 product has the following accession number(s) (GI #118582158) (NCBI Accession #Q4JIM5.1) (Uniprot Accession #Q4JIM5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL or DOK1. Required for adhesion-dependent phosphorylation of ARHGAP35 which promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Cellular Location: Cytoplasm, cytoskeleton. Tissue Location: Most abundant in adult mouse brain, especially in synapse-rich regions. Blood, Bone, Bone Marrow, Brain, Liver, Lung, Mammary Gland, Muscle, Prostate, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene. Abl2 also interacts with the following gene(s): Abi1, Abi2, Abl1, Crk, Rac1, Rin1.